Eli Lilly Presents P-III Clinical Development Program Results of Lebrikizumab for Atopic Dermatitis at 5th Annual RAD Congress
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- The secondary analysis from the P-III trial (Advocate 1& 2) in 869 patients evaluating lebrikizumab vs PBO. The (ADhere) study evaluating lebrikizumab + TCS vs PBO + TCS in 228 patients
- In 16wk. induction periods, the results showed an improvement or clearance of the face (62% vs 32% & 58% vs 22%) in the (Advocate 1& 2) study; 69% vs 46% in (ADhere) study, or hand dermatitis (67% vs 29% & 62% vs 19%) and 73% vs 43%, respectively. An additional secondary analysis demonstrated stable & long-lasting results of lebrikizumab (q4w or q2w)
- 80% in (ADvocate 1 & 2) trial maintained EASI-75 response, 70% maintained EASI-75 response with no or minimal fluctuations across 10 study visits @1yr. Lilly & partner Almirall S.A. expect regulatory decisions in the US & EU in 2023
Ref: Eli Lilly | Image: Eli Lilly
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